Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618373 | 0.93 | NPC1 (0.39) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6618430 | 0.92 | ALDH1A1 (0.38) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6617920 | 0.91 | KMT2A (0.40) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6618192 | 0.91 | NAMPT (0.36) | LMNARAB9ANPC1MEN1KMT2A | |
| SCHEMBL6617446 | 0.90 | CYP3A4 (0.39) | ALDH1A1LMNANPC1KDM4EMEN1 | |
| SCHEMBL6614450 | 0.89 | ALDH1A1 (0.41) | ALDH1A1LMNARAB9ANPC1KDM4E | |
| SCHEMBL6616711 | 0.89 | NPC1 (0.40) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL6674746 | 0.89 | MAPK14 (0.38) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6617181 | 0.88 | KDM4E (0.37) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6617729 | 0.88 | EPHX2 (0.37) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |