Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616479 | 0.93 | EPHX2 (0.38) | EPHX2NPC1RAB9AKMT2APLAT | |
| SCHEMBL6618495 | 0.90 | GNRHR (0.40) | EPHX2NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL6618430 | 0.90 | ALDH1A1 (0.38) | NPC1RAB9AKDM4EALDH1A1CASP3 | |
| SCHEMBL6630940 | 0.89 | KMT2A (0.41) | EPHX2NPC1RAB9AKMT2APLAT | |
| SCHEMBL6619186 | 0.89 | MEN1 (0.38) | EPHX2NPC1RAB9AKMT2APLAT | |
| SCHEMBL6617721 | 0.88 | EPHX2 (0.39) | EPHX2NPC1RAB9AKMT2APLAT | |
| SCHEMBL6619748 | 0.88 | ALDH1A1 (0.38) | EPHX2NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL6616726 | 0.88 | SLC1A2 (0.38) | NPC1RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL6603910 | 0.87 | NAMPT (0.42) | EPHX2KDM4ECRACR2APOLB | |
| SCHEMBL6617181 | 0.87 | KDM4E (0.37) | NPC1RAB9AKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |