Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.48 |
| ▸ | GCGR | P47871 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622165 | 0.80 | NOX1 (0.62) | NOX1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL6608693 | 0.80 | NOX1 (0.62) | NOX1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL6611375 | 0.79 | NOX1 (0.61) | NOX1ALOX5MAPK14MAPK11PTPN1 | |
| SCHEMBL8797319 | 0.79 | PTPN1 (0.72) | NOX1ALOX5PTPN1TP53MAPT | |
| SCHEMBL13679659 | 0.79 | NOX1 (0.61) | NOX1ALOX5PTPN1TP53MAPT | |
| SCHEMBL13679702 | 0.79 | PTPN1 (0.72) | NOX1ALOX5PTPN1TP53MAPT | |
| SCHEMBL6619832 | 0.78 | NOX1 (0.60) | NOX1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL13679657 | 0.78 | NOX1 (0.60) | NOX1ALOX5PTPN1TP53MAPT | |
| SCHEMBL6619898 | 0.77 | NOX1 (0.58) | NOX1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL1071183 | 0.76 | NOX1 (1.00) | NOX1ALOX5MAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-B1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | TAIJI BIOMEDICAL INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-2082740-A2 | Use of imidazole derivatives as MDR modulators | Taiji Biomedical, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |