Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493436 | 0.83 | MAOA (0.39) | MAOBMAOAGAAALDH1A1MAPT | |
| SCHEMBL3783560 | 0.81 | MAOA (0.41) | MAOBMAOAGAAALDH1A1KDM4E | |
| SCHEMBL10927335 | 0.81 | MAOA (0.41) | MAOBMAOAGAAALDH1A1KDM4E | |
| SCHEMBL8482200 | 0.81 | CA12 (0.41) | MAOBMAOAGAAALDH1A1MAPT | |
| SCHEMBL8482832 | 0.74 | KMT2A (0.46) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8486535 | 0.73 | HSD17B10 (0.40) | MAOBMAOAGAAALDH1A1MAPT | |
| SCHEMBL10592012 | 0.73 | MAOA (0.42) | MAOBMAOA | |
| SCHEMBL4244976 | 0.71 | AKR1B1 (0.39) | MAOBMAOAGAAALDH1A1MAPT | |
| SCHEMBL10718454 | 0.70 | FKBP5 (0.42) | MAOBMAOAGAAALDH1A1KDM4E | |
| SCHEMBL584704 | 0.70 | MAOA (0.46) | MAOBMAOAGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054673-B1 | BENZOXAZINE COMPOUNDS FOR ENHANCING SYNAPTIC RESPONSE | UNIV CALIFORNIA (US) | 2004-03-10 | — | — | EP | disclosed |
| EP-1054673-A4 | BENZOXAZINE COMPOUNDS FOR ENHANCING SYNAPTIC RESPONSE | CORTEX PHARMA INC (US) | 2001-07-18 | — | — | EP | disclosed |
| EP-1054673-A1 | BENZOXAZINE COMPOUNDS FOR ENHANCING SYNAPTIC RESPONSE | CORTEX PHARMACEUTICALS, INC. (US) | 2000-11-29 | — | — | EP | disclosed |
| US-5985871-A | TREATING SUBJECTS SUFFERING FROM IMPAIRED NERVOUS OR INTELLECTUAL FUNCTIONING DUE TO DEFICIENCIES IN THE NUMBER OF EXCITATORY SYNAPSES OR IN THE NUMBER OF AMPA RECEPTORS; USEFUL FOR TREATMENT OF SCHIZOPHRENIA, RELATED PSYCHOSES, AND | CORTEX PHARMACEUTICALS, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1999033469-A1 | BENZOXAZINE COMPOUNDS FOR ENHANCING SYNAPTIC RESPONSE | CORTEX PHARMACEUTICALS, INC. (US) | 1999-07-08 | — | — | WO | disclosed |