Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29578385 | 0.84 | TRPV4 (0.43) | PTGDR2TRPV4MRGPRX4CCR5CYP19A1 | |
| SCHEMBL214738 | 0.83 | ALDH1A1 (0.40) | PTGDR2TRPV4MAPTGAAALDH1A1 | |
| SCHEMBL10728257 | 0.81 | MRGPRX4 (0.49) | PTGDR2MRGPRX4MAPTARALDH1A1 | |
| SCHEMBL10730804 | 0.80 | F2 (0.41) | PTGDR2TRPV4MRGPRX4MAPTLMNA | |
| SCHEMBL1715337 | 0.80 | MRGPRX4 (0.48) | PTGDR2TRPV4MRGPRX4MAPTAR | |
| SCHEMBL1714334 | 0.80 | HRH3 (0.43) | PTGDR2TRPV4MRGPRX4CYP19A1CYP11B1 | |
| SCHEMBL19314042 | 0.80 | APP (0.47) | PTGDR2CYP19A1CYP11B1CYP11B2MAPT | |
| SCHEMBL6954239 | 0.79 | TRPV4 (0.53) | PTGDR2TRPV4MAPTGAAALDH1A1 | |
| SCHEMBL458608 | 0.79 | AR (0.51) | TRPV4MAPTARALDH1A1HPGD | |
| SCHEMBL29577649 | 0.77 | TRPV4 (0.43) | PTGDR2TRPV4MRGPRX4CCR5CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047695-B1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| US-6291475-B1 | 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| CN-1284956-A | Novel bispidine antiarrhythmic compounds | ASTRA ZENECA AKTIEBOLAG (SE) | 2001-02-21 | — | — | CN | disclosed |
| EP-1047695-A1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | AstraZeneca AB (SE) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999031100-A1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 1999-06-24 | — | — | WO | disclosed |