Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6639448 | 0.95 | C5AR1 (0.42) | C5AR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4766957 | 0.93 | C5AR1 (0.42) | C5AR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4766671 | 0.89 | C5AR1 (0.44) | C5AR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL651496 | 0.85 | JAK2 (0.42) | JAK2JAK1TYK2JAK3TLR7 | |
| SCHEMBL5074064 | 0.85 | LTA4H (0.45) | C5AR1TSHR | |
| SCHEMBL650270 | 0.84 | C5AR1 (0.43) | C5AR1TSHRPPARGPPARA | |
| SCHEMBL649162 | 0.84 | CRHR1 (0.46) | C5AR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL1912845 | 0.84 | ACKR3 (0.40) | C5AR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL5135765 | 0.83 | MEN1 (0.41) | C5AR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4766197 | 0.83 | JAK2 (0.42) | C5AR1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490343-A1 | NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS | Neurogen Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082829-A1 | NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |