SCHEMBL6620253

SCHEMBL6620253

COC(=O)c1ccc(O)c(CCO[Si](C)(C)C(C)(C)C)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.49
TP53 P04637 2/20 0.49
HPGD P15428 2/20 0.49
ALOX15 P16050 2/20 0.49
ALOX12 P18054 2/20 0.49
HSD17B10 Q99714 2/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
CKS1B P61024 1/20 0.49
SKP2 Q13309 1/20 0.49
HIF1A Q16665 1/20 0.49
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
CA12 O43570 2/20 0.48
CA7 P43166 2/20 0.48
CA9 Q16790 2/20 0.48
CA14 Q9ULX7 2/20 0.48
XDH P47989 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18054821 0.81 CA12 (0.47) ALDH1A1TP53HPGDALOX15ALOX12
SCHEMBL22801136 0.78 KDM4E (0.46) ALDH1A1TP53HPGDALOX15ALOX12
SCHEMBL4741778 0.78 CYP4F2 (0.59) ALDH1A1HPGDHIF1AMAPTKDM4E
SCHEMBL542559 0.76 CA1 (0.61) ALDH1A1TP53HPGDALOX15ALOX12
SCHEMBL30232935 0.76 CA1 (0.61) ALDH1A1TP53HPGDALOX15ALOX12
SCHEMBL15835801 0.75 MAPK1 (0.47) ALDH1A1MAPTKDM4EKMT2ANPC1
SCHEMBL25366639 0.75 MPO (0.41) ALDH1A1TP53HPGDALOX15ALOX12
SCHEMBL30530843 0.75 MPO (0.41) ALDH1A1TP53HPGDALOX15ALOX12
SCHEMBL16346874 0.75 NOTUM (0.45) ALDH1A1TP53HPGDALOX15ALOX12
SCHEMBL20860908 0.75 CA1 (0.59) ALDH1A1TP53HPGDALOX15ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0683781-B1 NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE METABASIS THERAPEUTICS INC (US) 2004-04-21 EP disclosed
US-5731432-A Inhibitors of adenosine monophosphate deaminase GENSIA SICOR INC. (US) 1998-03-24 US disclosed
EP-0683781-A4 NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE. GENSIA PHARMA (US) 1997-05-28 EP disclosed
EP-0683781-A1 NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE GENSIA PHARMACEUTICALS, INC. (US) 1995-11-29 EP disclosed
WO-1994018200-A1 NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE GENSIA, INC. (US) 1994-08-18 WO disclosed