Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3510029 | 0.84 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6617310 | 0.81 | CA12 (0.51) | NPC1SMN1; SMN2CYP4F2CYP4A11CYP1A2 | |
| SCHEMBL6208075 | 0.81 | CA12 (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL15557036 | 0.80 | CYP2C9 (0.55) | RAB9ANPC1MEN1KMT2ACYP1A2 | |
| SCHEMBL6618564 | 0.80 | CA12 (0.50) | NPC1CYP4F2CYP4A11CYP1A2 | |
| SCHEMBL5650127 | 0.79 | CYP4F2 (0.71) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9468569 | 0.77 | CA12 (0.54) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2404818 | 0.76 | NPC1 (0.59) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| Biphenyl SCHEMBL927814 | 0.76 | MEN1 (0.67) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| Biphenyl SCHEMBL27937069 | 0.76 | MEN1 (0.72) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683781-B1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | METABASIS THERAPEUTICS INC (US) | 2004-04-21 | — | — | EP | disclosed |
| US-5731432-A | Inhibitors of adenosine monophosphate deaminase | GENSIA SICOR INC. (US) | 1998-03-24 | — | — | US | disclosed |
| EP-0683781-A4 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE. | GENSIA PHARMA (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0683781-A1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | GENSIA PHARMACEUTICALS, INC. (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994018200-A1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | GENSIA, INC. (US) | 1994-08-18 | — | — | WO | disclosed |