Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.56 |
| ▸ | HTR2C | P28335 | 6/20 | 0.56 |
| ▸ | DRD1 | P21728 | 5/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.42 |
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5636917 | 1.00 | HTR2A (0.56) | HTR2AHTR2CDRD1SLC6A4OPRM1 | |
| SCHEMBL5513380 | 1.00 | HTR2A (0.56) | HTR2AHTR2CDRD1SLC6A4OPRM1 | |
| SCHEMBL6494486 | 0.85 | HTR2A (0.43) | HTR2AHTR2CDRD1SLC6A4OPRM1 | |
| SCHEMBL6494489 | 0.85 | HTR2A (0.43) | HTR2AHTR2CDRD1SLC6A4OPRM1 | |
| SCHEMBL5506007 | 0.83 | OPRM1 (0.60) | HTR2AHTR2CDRD1SLC6A4OPRM1 | |
| SCHEMBL30579711 | 0.83 | OPRM1 (0.60) | HTR2AHTR2CDRD1SLC6A4OPRM1 | |
| SCHEMBL22023339 | 0.83 | OPRM1 (0.60) | HTR2AHTR2CDRD1SLC6A4OPRM1 | |
| SCHEMBL5515239 | 0.82 | OPRM1 (0.49) | HTR2AHTR2CDRD1SLC6A4OPRM1 | |
| SCHEMBL5507296 | 0.81 | HTR2C (0.39) | HTR2AHTR2CDRD1SLC6A4DRD2 | |
| SCHEMBL5421686 | 0.79 | CCR3 (0.54) | HTR2AHTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189904-B1 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-09-22 | — | — | EP | disclosed |