Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.43 |
| ▸ | HTR2C | P28335 | 9/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | CCR3 | P51677 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494489 | 1.00 | HTR2A (0.43) | HTR2AHTR2CSLC6A4DRD1PARP1 | |
| SCHEMBL6784265 | 0.87 | HTR2A (0.42) | HTR2AHTR2CSLC6A4DRD1PARP1 | |
| SCHEMBL5636917 | 0.85 | HTR2A (0.56) | HTR2AHTR2CSLC6A4DRD1DRD2 | |
| SCHEMBL6622170 | 0.85 | HTR2A (0.56) | HTR2AHTR2CSLC6A4DRD1DRD2 | |
| SCHEMBL5513380 | 0.85 | HTR2A (0.56) | HTR2AHTR2CSLC6A4DRD1DRD2 | |
| SCHEMBL6504389 | 0.82 | HTR2A (0.35) | HTR2AHTR2CSLC6A4DRD1PARP1 | |
| SCHEMBL6491261 | 0.82 | HTR2A (0.35) | HTR2AHTR2CSLC6A4DRD1PARP1 | |
| SCHEMBL5416683 | 0.81 | HTR2A (0.42) | HTR2AHTR2CSLC6A4DRD2CCR3 | |
| SCHEMBL5416678 | 0.81 | HTR2A (0.42) | HTR2AHTR2CSLC6A4DRD2CCR3 | |
| SCHEMBL5421686 | 0.76 | CCR3 (0.54) | HTR2AHTR2CSLC6A4CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849619-B2 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-01 | — | — | US | disclosed |
| US-20040186094-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-09-23 | — | — | US | disclosed |
| US-6699852-B2 | ANTISEROTONIN AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-02 | — | — | US | disclosed |
| US-20020173503-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173503-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | HTR1A, HTR1B, HTR7 | HTR2A 21/4885HTR2C 11/4885SLC6A4 35/4885 |
| US-20040186094-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | HTR1A, HTR1B, HTR7 | HTR2A 21/4885HTR2C 11/4885SLC6A4 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.