Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619195 | 0.85 | PTGS2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL7542111 | 0.80 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL6619309 | 0.80 | PTGS2 (0.43) | PTGS2PTGS1HPGDMAPT | |
| SCHEMBL7536789 | 0.80 | PTGS2 (0.43) | PTGS2PTGS1HPGDMAPT | |
| SCHEMBL7489424 | 0.78 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL7566830 | 0.77 | PTGS2 (0.47) | PTGS2PTGS1HPGDMAPT | |
| SCHEMBL7482340 | 0.73 | PTGS2 (0.52) | PTGS2PTGS1MAPT | |
| SCHEMBL6470454 | 0.73 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL6620206 | 0.73 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL6623410 | 0.71 | CHRNA7 (0.43) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206474-B1 | SULFONYLPHENYLPYRAZOLE COMPOUNDS USEFUL AS COX-2 INHIBITORS | ABBOTT LAB (US) | 2004-05-26 | — | — | EP | disclosed |
| US-6472416-B1 | Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors | ABBOTT LABORATORIES | 2002-10-29 | — | — | US | disclosed |