Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622927 | 0.91 | HSD11B1 (0.42) | HSD11B1MEN1KMT2A | |
| SCHEMBL6167137 | 0.90 | HSD11B1 (0.42) | HSD11B1KDM4CMEN1KMT2AL3MBTL1 | |
| SCHEMBL6167402 | 0.89 | HSD11B1 (0.46) | HSD11B1KDM4CMEN1KMT2AL3MBTL1 | |
| SCHEMBL6165357 | 0.81 | HSD11B1 (0.40) | HSD11B1MEN1KMT2A | |
| SCHEMBL6608546 | 0.81 | HSD11B1 (0.36) | HSD11B1KDM4CL3MBTL1 | |
| SCHEMBL6167484 | 0.79 | HSD11B1 (0.43) | HSD11B1L3MBTL1 | |
| SCHEMBL6167437 | 0.78 | HSD11B1 (0.33) | HSD11B1 | |
| SCHEMBL6611947 | 0.75 | MLLT3 (0.45) | HSD11B1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6609350 | 0.73 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL6608114 | 0.73 | NPY2R (0.35) | HSD11B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |