Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27595536 | 0.87 | ALDH1A1 (0.49) | POLBNPC1RAB9AALDH1A1GAA | |
| SCHEMBL6619252 | 0.85 | PTGER4 (0.48) | POLBNPC1RAB9AALDH1A1GAA | |
| SCHEMBL6770796 | 0.83 | HCAR3 (0.51) | POLBNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL14708905 | 0.76 | ITK (0.38) | ITK | |
| SCHEMBL7973995 | 0.73 | PRSS1 (0.50) | ALDH1A1GAASMN1; SMN2KDM4EMAPT | |
| SCHEMBL14708889 | 0.72 | AAK1 (0.41) | NPC1RAB9AALDH1A1GAAALOX15 | |
| SCHEMBL9001766 | 0.72 | ALDH1A1 (0.66) | POLBNPC1RAB9AALDH1A1GAA | |
| SCHEMBL3455371 | 0.71 | ALDH1A1 (0.58) | POLBNPC1RAB9AALDH1A1GAA | |
| SCHEMBL14708892 | 0.70 | HDAC1 (0.46) | ALDH1A1GAAKDM4EMAPTHSD17B10 | |
| SCHEMBL6635249 | 0.70 | ITK (0.64) | ITKCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825219-B2 | NITROGEN COMPOUNDS SUCH AS 4-((5-(CYCLOHEXYL-METHYL-CARBAMOYL) -2(THIOPHENE-2-CARBONYL)-AMINO)BENZIMIDAZOL-1-YL)-BUTYRIC ACID ADMINISTERED FOR THE PROPHYLAXIS OF INFLAMMATORY, IMMUNOLOGICAL AND ALLERGIC DISORDERS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1448199-A1 | BENZIMIDAZOLES USEFUL AS PROTEIN KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-08-25 | — | — | EP | disclosed |
| US-20030144281-A1 | Substituted benzimidazole compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-07-31 | — | — | US | disclosed |
| WO-2003041708-A1 | BENZIMIDAZOLES USEFUL AS PROTEIN KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144281-A1 | Substituted benzimidazole compounds | HRH2, HRH4, HRH1 | POLB 1972/4885NPC1 2229/4885RAB9A 1916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.