Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.74 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.74 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10144991 | 0.91 | CYP4F2 (0.69) | CYP4F2CYP4A11MEP1BNPC1RAB9A | |
| SCHEMBL1793142 | 0.87 | CYP4F2 (0.81) | CYP4F2CYP4A11MEP1BNPC1RAB9A | |
| SCHEMBL8723505 | 0.86 | CYP4F2 (0.74) | CYP4F2CYP4A11MEP1BNPC1RAB9A | |
| SCHEMBL8799839 | 0.85 | CYP4F2 (1.00) | CYP4F2CYP4A11MEP1BNPC1RAB9A | |
| SCHEMBL28280189 | 0.84 | CYP4F2 (0.76) | CYP4F2CYP4A11MEP1BNPC1RAB9A | |
| SCHEMBL20178551 | 0.84 | CYP4F2 (0.76) | CYP4F2CYP4A11MEP1BNPC1RAB9A | |
| SCHEMBL11587961 | 0.84 | CYP4F2 (0.76) | CYP4F2CYP4A11MEP1BNPC1RAB9A | |
| SCHEMBL17563119 | 0.84 | CYP4F2 (0.76) | CYP4F2CYP4A11MEP1BNPC1RAB9A | |
| SCHEMBL12035616 | 0.83 | CYP4F2 (0.75) | CYP4F2CYP4A11MEP1BNPC1RAB9A | |
| SCHEMBL13324061 | 0.83 | CYP4F2 (0.74) | CYP4F2CYP4A11MEP1BNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
| EP-1910272-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009250-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | CYP4F2 562/4885CYP4A11 231/4885MEP1B 2305/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | CYP4F2 257/4885CYP4A11 53/4885MEP1B 1045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.