Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP6 | P51161 | 1/20 | 0.55 |
| ▸ | PNP | P00491 | 2/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 3/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MASP2 | O00187 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29669307 | 0.88 | FABP6 (0.55) | FABP6PNPNUDT1BRD4MMP12 | |
| SCHEMBL6581218 | 0.77 | MEN1 (0.46) | FABP6PNPALDH1A1MEN1KMT2A | |
| SCHEMBL5679402 | 0.76 | NUDT1 (0.51) | FABP6PNPNUDT1BRD4RPS6KA3 | |
| SCHEMBL2541920 | 0.76 | CBFB (0.49) | FABP6PNPNUDT1MMP12RPS6KA3 | |
| SCHEMBL6856394 | 0.73 | PLAU (0.49) | FABP6PNPNUDT1BRD4MMP12 | |
| SCHEMBL6581987 | 0.72 | FABP6 (0.40) | FABP6PNPNUDT1BRD4MMP12 | |
| SCHEMBL393703 | 0.71 | FABP6 (1.00) | FABP6NUDT1ALDH1A1MASP2MEN1 | |
| Bromide SCHEMBL23295657 | 0.69 | FABP6 (0.96) | FABP6NUDT1ALDH1A1MASP2MEN1 | |
| Water SCHEMBL10985661 | 0.69 | FABP6 (0.96) | FABP6NUDT1ALDH1A1MASP2MEN1 | |
| SCHEMBL17276018 | 0.69 | NUDT1 (0.49) | FABP6PNPNUDT1MMP12RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487824-A1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-22 | — | — | EP | claimed |
| WO-2003074515-A1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-12 | — | — | WO | claimed |
| EP-1487824-A1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003074515-A1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-12 | — | — | WO | disclosed |