Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625088 | 0.91 | SLC6A9 (0.39) | SIGMAR1SLC6A9TACR1KDM4EHSD17B10 | |
| SCHEMBL6642882 | 0.88 | CHRM5 (0.50) | CHRM5CHRM3SIGMAR1SLC6A9OPRD1 | |
| SCHEMBL6628233 | 0.85 | SLC6A9 (0.36) | SIGMAR1SLC6A9TACR1KDM4EHSD17B10 | |
| SCHEMBL19067312 | 0.85 | CHRM5 (0.40) | CHRM5CHRM3SIGMAR1SLC6A9OPRD1 | |
| SCHEMBL12156548 | 0.83 | SLC6A9 (0.44) | SIGMAR1SLC6A9TACR1KDM4EHSD17B10 | |
| SCHEMBL408919 | 0.83 | SLC6A9 (0.44) | SIGMAR1SLC6A9TACR1KDM4EHSD17B10 | |
| SCHEMBL7593926 | 0.83 | SLC6A9 (0.44) | SIGMAR1SLC6A9TACR1KDM4EHSD17B10 | |
| SCHEMBL12156561 | 0.83 | SLC6A9 (0.44) | SIGMAR1SLC6A9TACR1KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL29697028 | 0.82 | SLC6A9 (0.43) | SIGMAR1SLC6A9TACR1KDM4EHSD17B10 | |
| SCHEMBL16800527 | 0.81 | CHRM5 (0.48) | CHRM5CHRM3SIGMAR1OPRD1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998476-B1 | 1,4,7,10-TETRAAZABICYCLO 8.2.2]TETRADECAN-2-ONE, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF FOR THE PREPARATION OF TETRAAZAMACROCYCLES | BRACCO SPA (IT) | 2004-05-06 | — | — | EP | disclosed |
| US-6162912-A | Process of preparing tetraacetic acid derivatives | DIBRA S.P.A. (IT) | 2000-12-19 | — | — | US | disclosed |
| US-6048980-A | AMINATION WITH DEHYDROHALOGENATION FOLLOWED BY HYDROLYSIS OF ESTER GROUP | DIBRA S.P.A (IT) | 2000-04-11 | — | — | US | disclosed |
| US-6028194-A | SYNTHESIS OF GADOTERIDOL AND GADOBUTROL CONTRAST AGENTS FOR THE RESONANCE TECHNIQUE (MAGNETIC RESONANCE IMAGING) | DIBRA S.P.A. (IT) | 2000-02-22 | — | — | US | disclosed |
| US-6020485-A | Process for producing tetraazabicyclo monoacetic acid | DIBRA S.P.A. (IT) | 2000-02-01 | — | — | US | disclosed |
| US-5977353-A | 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles | DIBRA S.P.A. (IT) | 1999-11-02 | — | — | US | disclosed |