Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 4/20 | 0.42 |
| ▸ | MME | P08473 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624100 | 1.00 | CYP2C9 (0.45) | CYP2C9ALDH1A1MAPTFAAHMME | |
| SCHEMBL4189346 | 0.89 | ALDH1A1 (0.50) | CYP2C9ALDH1A1MAPTFAAHMME | |
| SCHEMBL3159946 | 0.89 | ALDH1A1 (0.50) | CYP2C9ALDH1A1MAPTFAAHMME | |
| SCHEMBL10076082 | 0.89 | ALDH1A1 (0.50) | CYP2C9ALDH1A1MAPTFAAHMME | |
| SCHEMBL11429905 | 0.82 | MME (0.52) | CYP2C9ALDH1A1MAPTFAAHMME | |
| SCHEMBL16199258 | 0.82 | MME (0.52) | CYP2C9ALDH1A1MAPTFAAHMME | |
| SCHEMBL23894144 | 0.76 | PSMB5 (0.53) | ALDH1A1MAPTFAAHMMEACE | |
| SCHEMBL16892770 | 0.74 | MME (0.47) | ALDH1A1MAPTFAAHMMEACE | |
| SCHEMBL5313816 | 0.74 | MME (0.47) | ALDH1A1MAPTFAAHMMEACE | |
| SCHEMBL6366655 | 0.74 | MME (0.47) | ALDH1A1MAPTFAAHMMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395589-A1 | IMIDAZO-TRIAZINE DERIVATIVES AS PDE 5 INHIBITORS | Pfizer Limited (GB) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002079203-A1 | IMIDAZO-TRIAZINE DERIVATIVES AS PDE 5 INHIBITORS | PFIZER LIMITED (GB) | 2002-10-10 | — | — | WO | disclosed |