Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034786 | 0.76 | — | — | |
| SCHEMBL14335170 | 0.73 | TSHR (0.46) | NPC1POLBMAPTRAB9AKMT2A | |
| SCHEMBL7493066 | 0.73 | HIF1A (0.39) | NPC1POLBMAPTRAB9AKMT2A | |
| SCHEMBL14334179 | 0.71 | MAPT (0.33) | NPC1POLBMAPTRAB9AKMT2A | |
| SCHEMBL1258486 | 0.70 | HIF1A (0.44) | NPC1POLBMAPTRAB9AKMT2A | |
| SCHEMBL9252984 | 0.69 | NPC1 (0.30) | NPC1POLBMAPTRAB9AKMT2A | |
| SCHEMBL5789575 | 0.69 | NPC1 (0.33) | NPC1POLBMAPTRAB9AKMT2A | |
| SCHEMBL14333827 | 0.69 | HCAR2 (0.34) | NPC1POLBMAPTRAB9AKMT2A | |
| SCHEMBL14334534 | 0.68 | L3MBTL1 (0.31) | — | |
| SCHEMBL7001110 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444223-A1 | AMINOPYRIMIDINES AND -PYRIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040131-A1 | AMINOPYRIMIDINES AND PYRIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-15 | — | — | WO | disclosed |