Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23052369 | 0.87 | KMT2A (0.62) | ALDH1A1SMN1; SMN2HTTLMNAHPGD | |
| SCHEMBL6626965 | 0.85 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2HTTLMNAHPGD | |
| SCHEMBL6624619 | 0.82 | SIGMAR1 (0.57) | ALDH1A1SMN1; SMN2HTTHDAC3KMT2A | |
| SCHEMBL5649817 | 0.82 | KMT2A (0.52) | ALDH1A1SMN1; SMN2HTTLMNAKMT2A | |
| SCHEMBL8397048 | 0.82 | GBA1 (0.58) | ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL8391910 | 0.82 | GBA1 (0.58) | ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL6624376 | 0.82 | USP2 (0.62) | ALDH1A1SMN1; SMN2HTTKMT2AUSP2 | |
| SCHEMBL8393373 | 0.80 | GBA1 (0.60) | ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL29183287 | 0.80 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2HTTLMNAHPGD | |
| SCHEMBL12169387 | 0.79 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HTTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986384-A4 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2004-09-15 | — | — | EP | disclosed |
| US-6310095-B1 | INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE | UNIVERSITY OF PITTSBURGH | 2001-10-30 | — | — | US | disclosed |
| EP-0986384-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998050029-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |