Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624638 | 1.00 | ALDH1A1 (0.58) | ALDH1A1MAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL6625930 | 0.84 | MAPT (0.46) | ALDH1A1MAPTLMNARAB9ANPC1 | |
| SCHEMBL6625925 | 0.84 | MAPT (0.46) | ALDH1A1MAPTLMNARAB9ANPC1 | |
| SCHEMBL6625138 | 0.83 | MAPT (0.42) | ALDH1A1MAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL28750028 | 0.82 | ALDH1A1 (0.55) | ALDH1A1MAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL28750029 | 0.82 | ALDH1A1 (0.55) | ALDH1A1MAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL6627575 | 0.81 | MAPT (0.49) | ALDH1A1MAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL6627579 | 0.81 | MAPT (0.49) | ALDH1A1MAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL9911350 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL483951 | 0.80 | HTT (0.55) | ALDH1A1MAPTLMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116417-A1 | Thiohydantoins and use thereof for treating diabetes | LABORATOIRES FOURNIER SA (FR) | 2004-06-17 | — | — | US | disclosed |
| EP-1373219-A1 | THIOHYDANTOINS AND USE THEREOF FOR TREATING DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002081453-A1 | THIOHYDANTOINS AND USE THEREOF FOR TREATING DIABETES | LABORATOIRES FOURNIER SA (FR) | 2002-10-17 | — | — | WO | disclosed |