Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626884 | 0.86 | HTT (0.46) | HTTPTK2BMEN1KMT2AGAA | |
| SCHEMBL6623903 | 0.84 | HTT (0.44) | HTTPTK2BADORA2AADORA2BALDH1A1 | |
| SCHEMBL6627208 | 0.84 | HTT (0.44) | HTTPTK2BGAAPARP1CYP1A2 | |
| SCHEMBL6623153 | 0.84 | HTT (0.44) | HTTPTK2BADORA2AADORA2BHSD17B10 | |
| SCHEMBL6622604 | 0.84 | HTT (0.44) | HTTPTK2BSIRT2PARP1 | |
| SCHEMBL6625269 | 0.83 | HTT (0.46) | HTTPTK2BALDH1A1GAAHSD17B10 | |
| SCHEMBL6623944 | 0.81 | PARP1 (0.46) | HTTPTK2BADORA2AADORA2BSMN1; SMN2 | |
| SCHEMBL6625624 | 0.75 | HTT (0.36) | HTTPTK2BADORA2AADORA2BMEN1 | |
| SCHEMBL6627070 | 0.70 | BRD4 (0.48) | HTTPTK2BMEN1ALDH1A1KMT2A | |
| SCHEMBL6623859 | 0.68 | PARP1 (0.41) | ALDH1A1GAAHSD17B10PARP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858996-B1 | NERVE CELL PROTECTIVE AGENTS | MOCHIDA PHARM CO LTD (JP) | 2004-10-27 | — | — | EP | disclosed |
| US-6040331-A | Nerve cell protective agents | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-03-21 | — | — | US | disclosed |
| EP-0858996-A1 | NERVE CELL PROTECTIVE AGENTS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-19 | — | — | EP | disclosed |