SCHEMBL6624686

SCHEMBL6624686

c1ccc(-c2ccc(N3CC4C[C@H]3CN4)nn2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.61
CSNK1E P49674 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL454539 1.00 CHRNA7 (0.61) CHRNA7CSNK1E
SCHEMBL5354493 0.84 CHRNA7 (0.45) CHRNA7CSNK1E
SCHEMBL1792911 0.84 CHRNA7 (0.48) CHRNA7
SCHEMBL18291307 0.79 CHRNB2 (0.59)
SCHEMBL6625406 0.79 CHRNB2 (0.61)
SCHEMBL2963520 0.79 CHRNB2 (0.61)
SCHEMBL5034127 0.79 CHRNB2 (0.61)
SCHEMBL20038439 0.79 CHRNB2 (0.48)
SCHEMBL18291726 0.79 CHRNB2 (0.59)
Hydrochloric Acid SCHEMBL7250231 0.78 CHRNB2 (0.59)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144413-B1 2,5-DIAZABICYCLO 2.2.1]HEPTANE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USES SANOFI SYNTHELABO (FR) 2004-03-17 EP disclosed
US-6635645-B1 Nicotinic receptors dysfunction SANOFI-SYNTHELABO (FR) 2003-10-21 US disclosed