Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624686 | 0.84 | CHRNA7 (0.61) | CHRNA7CSNK1E | |
| SCHEMBL454539 | 0.84 | CHRNA7 (0.61) | CHRNA7CSNK1E | |
| SCHEMBL5345627 | 0.84 | CHRNB2 (0.47) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5353963 | 0.82 | CHRNB2 (0.45) | CSNK1ECHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5355007 | 0.77 | CHRNA7 (0.69) | CHRNA7 | |
| SCHEMBL20038439 | 0.73 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL18291726 | 0.73 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL18291307 | 0.73 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL6625406 | 0.73 | CHRNB2 (0.61) | CHRNB2CHRNA4 | |
| SCHEMBL5034127 | 0.73 | CHRNB2 (0.61) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300933-B2 | Diazabicyclic biaryl derivatives | NEUROSEARCH A/S (DK) | 2007-11-27 | — | — | US | claimed |
| EP-1506200-B1 | DIAZABICYCLIC BIARYL DERIVATIVES | NEUROSEARCH AS (DK) | 2006-12-20 | — | — | EP | claimed |
| JP-2005524713-A | — | — | 2005-08-18 | — | — | JP | claimed |
| US-20050131236-A1 | Novel diazabicyclic biaryl derivatives | ANIONA APS (DK) | 2005-06-16 | — | — | US | claimed |
| EP-1506200-A2 | NOVEL DIAZABICYCLIC BIARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2005-02-16 | — | — | EP | claimed |
| WO-2003094831-A2 | NOVEL DIAZABICYCLIC BIARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2003-11-20 | — | — | WO | claimed |
| US-7300933-B2 | Diazabicyclic biaryl derivatives | NEUROSEARCH A/S (DK) | 2007-11-27 | — | — | US | disclosed |
| EP-1506200-B1 | DIAZABICYCLIC BIARYL DERIVATIVES | NEUROSEARCH AS (DK) | 2006-12-20 | — | — | EP | disclosed |
| US-20050131236-A1 | Novel diazabicyclic biaryl derivatives | ANIONA APS (DK) | 2005-06-16 | — | — | US | disclosed |
| EP-1506200-A2 | NOVEL DIAZABICYCLIC BIARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003094831-A2 | NOVEL DIAZABICYCLIC BIARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131236-A1 | Novel diazabicyclic biaryl derivatives | CHRNA6, CHRNA3, CHRNA2 | CHRNA7 5/4885CSNK1E 2873/4885CHRNB2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.