Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.63 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31689573 | 0.85 | CASP3 (0.62) | CASP3FKBP1AHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL16014995 | 0.81 | CASP3 (0.62) | CASP3FKBP1AHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL16129184 | 0.81 | CASP3 (0.62) | CASP3FKBP1AHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL17323673 | 0.81 | CASP3 (0.62) | CASP3HCRTR1HCRTR2ALDH1A1KDM4E | |
| SCHEMBL16014994 | 0.81 | CASP3 (0.62) | CASP3FKBP1AHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL31645000 | 0.81 | CASP3 (0.59) | CASP3HCRTR1HCRTR2ALDH1A1KDM4E | |
| SCHEMBL7086061 | 0.80 | CASP3 (0.61) | CASP3ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL7086065 | 0.80 | CASP3 (0.61) | CASP3ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL8248205 | 0.78 | CASP3 (0.59) | CASP3FKBP1AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6535370 | 0.78 | CASP3 (1.00) | CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769498-B9 | Sulfonamide derivatives with elastase inhibiting activity | ONO PHARMACEUTICAL CO (JP) | 2004-11-10 | — | — | EP | disclosed |
| EP-0769498-B9 | Sulfonamide derivatives with elastase inhibiting activity | ONO PHARMACEUTICAL CO (JP) | 2004-11-10 | — | — | EP | disclosed |
| EP-0769498-B1 | Sulfonamide derivatives with elastase inhibiting activity | ONO PHARMACEUTICAL CO (JP) | 2004-03-17 | — | — | EP | disclosed |
| EP-0769498-B1 | Sulfonamide derivatives with elastase inhibiting activity | ONO PHARMACEUTICAL CO (JP) | 2004-03-17 | — | — | EP | disclosed |
| US-5998410-A | Sulfonamide derivatives | ONO PHARMACEUTICALS CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| US-5795890-A | ELASTASE INHIBITORS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-08-18 | — | — | US | disclosed |
| EP-0769498-A1 | Sulfonamide derivatives with elastase inhibiting activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-04-23 | — | — | EP | disclosed |