Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086061 | 1.00 | CASP3 (0.61) | CASP3ALDH1A1HTTMAPK1TSHR | |
| SCHEMBL16014994 | 0.86 | CASP3 (0.62) | CASP3ALDH1A1HTTMMP9MMP1 | |
| SCHEMBL17323673 | 0.86 | CASP3 (0.62) | CASP3ALDH1A1HTTMMP9MMP1 | |
| SCHEMBL16129184 | 0.86 | CASP3 (0.62) | CASP3ALDH1A1HTTMMP9MMP1 | |
| SCHEMBL16014995 | 0.86 | CASP3 (0.62) | CASP3ALDH1A1HTTMMP9MMP1 | |
| SCHEMBL7085725 | 0.86 | CASP3 (0.58) | CASP3ALDH1A1HTTMAPK1TSHR | |
| SCHEMBL7085726 | 0.86 | CASP3 (0.58) | CASP3ALDH1A1HTTMAPK1TSHR | |
| SCHEMBL8248205 | 0.83 | CASP3 (0.59) | CASP3ALDH1A1HTTMAPK1MMP9 | |
| SCHEMBL5717004 | 0.81 | CASP3 (0.59) | CASP3ALDH1A1HTTMMP1MMP13 | |
| SCHEMBL6624711 | 0.80 | CASP3 (0.63) | CASP3ALDH1A1TSHRMMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252141-B1 | TOSYLPROLINE ANALOGS AS THYMIDYLATE SYNTHASE INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2003-07-30 | — | — | EP | disclosed |
| EP-1252141-A1 | TOSYLPROLINE ANALOGS AS THYMIDYLATE SYNTHASE INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001056987-A1 | TOSYLPROLINE ANALOGS AS THYMIDYLATE SYNTHASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. (US) | 2001-08-09 | — | — | WO | disclosed |
| US-6143776-A | Tosylproline analogs as thymidylate synthase inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2000-11-07 | — | — | US | disclosed |