Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.40 |
| ▸ | GCGR | P47871 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | MATK | P42679 | 1/20 | 0.37 |
| ▸ | FRK | P42685 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624049 | 0.81 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL6622926 | 0.81 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL6622768 | 0.78 | PTGS1 (0.54) | PTGS2PTGS1 | |
| SCHEMBL6622744 | 0.77 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL6624935 | 0.70 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL6595931 | 0.69 | MAPK14 (0.70) | MAPK14PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL9208024 | 0.69 | MAPK14 (0.46) | MAPK14PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL7777683 | 0.68 | MAPK14 (0.49) | MAPK14PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL6621543 | 0.66 | PTGS2 (0.53) | PTGS2 | |
| SCHEMBL6621848 | 0.66 | PTGS2 (0.54) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206474-B1 | SULFONYLPHENYLPYRAZOLE COMPOUNDS USEFUL AS COX-2 INHIBITORS | ABBOTT LAB (US) | 2004-05-26 | — | — | EP | disclosed |
| US-6472416-B1 | Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors | ABBOTT LABORATORIES | 2002-10-29 | — | — | US | disclosed |