Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4844072 | 0.84 | KDM4E (0.49) | MAPTL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6629638 | 0.81 | MAPT (0.57) | MAPTL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2876019 | 0.76 | HSP90AA1 (0.50) | MAPTL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2876016 | 0.76 | KDM4E (0.43) | MAPTL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL13064595 | 0.75 | DHFR (0.47) | MAPTL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL13020880 | 0.74 | KDM4E (0.41) | MAPTL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4839488 | 0.73 | KDM4E (0.57) | MAPTL3MBTL1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL10847225 | 0.73 | HSP90AA1 (0.43) | MAPTKDM4EHTTMEN1KMT2A | |
| SCHEMBL7699598 | 0.70 | KDM4E (0.49) | MAPTL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6623348 | 0.69 | MEN1 (0.69) | MAPTL3MBTL1ALDH1A1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976753-B1 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2004-01-02 | — | — | EP | disclosed |
| US-6222035-B1 | AS ADENOSINE A.SUB.2A RECEPTOR ANTAGONISTS AND ARE USEFUL FOR THERAPY OR OR PROPHYLAXIS OF VARIOUS DISEASES INDUCED BY HYPERACTIVITY OF ADENOSINE A.SUB.2A RECEPTORS SUCH AS PARKINSON'S DISEASE, SENILE DEMENTIA OR DEPRESSION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-24 | — | — | US | disclosed |
| EP-0976753-A1 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-02 | — | — | EP | disclosed |