Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876016 | 0.88 | KDM4E (0.43) | KDM4EHTTNPC1RAB9AHSP90AA1 | |
| SCHEMBL2876019 | 0.88 | HSP90AA1 (0.50) | KDM4EHTTNPC1RAB9AHSP90AA1 | |
| SCHEMBL13064595 | 0.86 | DHFR (0.47) | KDM4EHTTNPC1RAB9AHSP90AA1 | |
| SCHEMBL13020880 | 0.85 | KDM4E (0.41) | KDM4EHTTNPC1RAB9AHSP90AA1 | |
| SCHEMBL7699598 | 0.84 | KDM4E (0.49) | KDM4EHTTNPC1RAB9AHSP90AA1 | |
| SCHEMBL6624890 | 0.84 | MAPT (0.55) | KDM4EHTTNPC1RAB9AHSP90AA1 | |
| SCHEMBL4839488 | 0.84 | KDM4E (0.57) | KDM4EHTTNPC1RAB9AHSP90AA1 | |
| SCHEMBL10847225 | 0.84 | HSP90AA1 (0.43) | KDM4EHTTNPC1RAB9AHSP90AA1 | |
| SCHEMBL7811229 | 0.82 | CYP1A2 (0.58) | KDM4EHTTNPC1RAB9ADCUN1D1 | |
| SCHEMBL31504610 | 0.79 | L3MBTL1 (0.54) | KDM4EHTTNPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6176909-B1 | IN POLYMERIC BINDER | XEROX CORPORATION | 2001-01-23 | — | — | US | claimed |
| US-20090076047-A1 | 2-Substituted Hydroxylaminopyrimidine, Method for the Production and the Use Thereof in the Form of Pesticides | BASF AKTIENGESELLSCHAFT (DE) | 2009-03-19 | — | — | US | disclosed |
| US-7452892-B2 | Triazolopyrimidine cannabinoid receptor 1 antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-18 | — | — | US | disclosed |
| US-20080132522-A1 | 2-Substituted Pyrimidines, Method for Their Production and Their Use for Controlling Pathogenic Fungi | BASF AKTIENGESELLSCHAFT (DE) | 2008-06-05 | — | — | US | disclosed |
| US-20070208037-A1 | FUNGICIDAL 5-PHENYL SUBSTITUTED 2-(CYANOAMINO) PYRIMIDINES | PEES KLAUS-JUERGEN | 2007-09-06 | — | — | US | disclosed |
| US-7230104-B2 | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines | BASF AKTIENGESELLSCHAFT (DE) | 2007-06-12 | — | — | US | disclosed |
| WO-2006138734-A1 | TRIAZOLOPYRIMIDINE CANNABINOID RECEPTOR 1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-28 | — | — | WO | disclosed |
| US-20060287341-A1 | Triazolopyrimidine cannabinoid receptor 1 antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2006-12-21 | — | — | US | disclosed |
| US-20050282828-A1 | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines | PEES KLAUS-JUERGEN | 2005-12-22 | — | — | US | disclosed |
| US-20050282847-A1 | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines | PEES KLAUS-JUERGEN | 2005-12-22 | — | — | US | disclosed |
| WO-2001017976-A1 | BIS-SULFONAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-03-15 | — | — | WO | disclosed |
| US-6176909-B1 | IN POLYMERIC BINDER | XEROX CORPORATION | 2001-01-23 | — | — | US | disclosed |
| EP-0976753-A1 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-02 | — | — | EP | disclosed |
| EP-0714896-A1 | INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION | VITA-INVEST, S.A. (ES) | 1996-06-05 | — | — | EP | disclosed |
| EP-0121341-B1 | TRIAZOLO(4,3-C)PYRIMIDINES AND TRIAZOLO(1,5-C)PYRIMIDINES SUBSTITUTED BY NITROGEN-CONTAINING HETEROCYCLIC RINGS | RIKER LABORATORIES, INCORPORATED (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4612375-A | Substituted 4-hydrazino-pyrimides as intermediates for triazolo [4,3-c]pyrimidines | RIKER LABORATORIES, INC. (US) | 1986-09-16 | — | — | US | disclosed |
| US-4536579-A | BRONCHODILATING AGENTS | RIKER LABORATORIES, INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4532242-A | Bronchodilator agents | RIKER LABORATORIES, INC. (US) | 1985-07-30 | — | — | US | disclosed |
| US-4477450-A | BRONCHODILATORS | RIKER LABORATORIES, INC. (US) | 1984-10-16 | — | — | US | disclosed |
| EP-0121341-A1 | Triazolo(4,3-c)pyrimidines and triazolo(1,5-c)pyrimidines substituted by nitrogen-containing heterocyclic rings | RIKER LABORATORIES, INCORPORATED (US) | 1984-10-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287341-A1 | Triazolopyrimidine cannabinoid receptor 1 antagonists | CNR1, CNR2, GPR68 | KDM4E 3169/4885HTT 3943/4885NPC1 1139/4885 |
| US-20080132522-A1 | 2-Substituted Pyrimidines, Method for Their Production and Their Use for Controlling Pathogenic Fungi | TYMS, TYMP, PNPO | KDM4E 1488/4885HTT 3837/4885NPC1 3667/4885 |
| US-20050282828-A1 | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines | CBR3, CBR1, CYP3A5 | KDM4E 1747/4885HTT 4218/4885NPC1 2326/4885 |
| US-20070208037-A1 | FUNGICIDAL 5-PHENYL SUBSTITUTED 2-(CYANOAMINO) PYRIMIDINES | CBR3, NOX5, CBR1 | KDM4E 1898/4885HTT 4154/4885NPC1 2387/4885 |
| US-20050282847-A1 | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines | CBR3, NOX5, CBR1 | KDM4E 2207/4885HTT 4163/4885NPC1 1946/4885 |
| US-20090076047-A1 | 2-Substituted Hydroxylaminopyrimidine, Method for the Production and the Use Thereof in the Form of Pesticides | DHFR, DPYD, DDT | KDM4E 2523/4885HTT 686/4885NPC1 4676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.