Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84933 | 0.94 | TSHR (0.59) | TSHRPOLBTDP1SMN1; SMN2KMT2A | |
| SCHEMBL8433585 | 0.84 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1 | |
| Formic Acid SCHEMBL6608165 | 0.84 | ALDH1A1 (0.51) | POLBSMN1; SMN2KMT2AALDH1A1 | |
| Formic Acid SCHEMBL3265060 | 0.82 | TDP1 (0.53) | TSHRPOLBTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5519114 | 0.81 | SMN1; SMN2 (0.56) | TSHRPOLBTDP1SMN1; SMN2KMT2A | |
| SCHEMBL85431 | 0.81 | TSHR (0.60) | TSHRPOLBTDP1SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL5843426 | 0.79 | TSHR (0.62) | TSHRPOLBTDP1SMN1; SMN2KMT2A | |
| SCHEMBL9602488 | 0.79 | TSHR (0.58) | TSHRPOLBTDP1SMN1; SMN2KMT2A | |
| SCHEMBL23929061 | 0.78 | SMN1; SMN2 (0.82) | TSHRPOLBTDP1SMN1; SMN2KMT2A | |
| SCHEMBL5176558 | 0.78 | SMN1; SMN2 (0.59) | TSHRPOLBTDP1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444201-A1 | 2-(3-SULFONYLAMINO-2-OXOPYRROLIDIN-1-YL)PROPANAMIDES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003043981-A1 | 2-(3-SULFONYLAMINO-2-OXOPYRROLIDIN-1-YL)PROPANAMIDES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-05-30 | — | — | WO | disclosed |