Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.41 |
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625721 | 0.85 | PBRM1 (0.48) | PIM1PIM2CDK5CDK5R1CLK1 | |
| SCHEMBL6624281 | 0.80 | PIM3 (0.42) | PKN1PKN2PIM1DYRK1APIM3 | |
| SCHEMBL6624277 | 0.79 | RAD52 (0.51) | DYRK1AJAK2CSNK2A1 | |
| SCHEMBL2688190 | 0.78 | PARP1 (0.56) | MAPK8MAPK9MAPK10PKN1PKN2 | |
| SCHEMBL10136632 | 0.78 | PARP1 (0.50) | MAPK8MAPK9MAPK10PKN1PKN2 | |
| SCHEMBL21801215 | 0.77 | MAPK8 (0.53) | MAPK8MAPK9MAPK10PKN1PKN2 | |
| SCHEMBL29715210 | 0.77 | MAPK8 (0.53) | MAPK8MAPK9MAPK10PKN1PKN2 | |
| SCHEMBL6622666 | 0.75 | LMNA (0.50) | PIM1PIM3MPLJAK2KDM4E | |
| SCHEMBL6629158 | 0.74 | PIM3 (0.46) | PIM1PIM3MPLCDK4CCND1 | |
| SCHEMBL8487413 | 0.73 | JAK2 (0.52) | PIM1PIM3MPLJAK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831094-B1 | FUSED POLYCYCLIC HETEROCYCLE DERIVATIVES | EISAI CO LTD (JP) | 2004-12-08 | — | — | EP | disclosed |
| EP-0831094-A1 | FUSED POLYCYCLIC HETEROCYCLE DERIVATIVES | Eisai Co., Ltd. (JP) | 1998-03-25 | — | — | EP | disclosed |