Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624281 | 0.77 | PIM3 (0.42) | PIM3PIM1MPLJAK2NR4A2 | |
| SCHEMBL6622666 | 0.75 | LMNA (0.50) | PIM3CHEK1PIM1MPLJAK2 | |
| SCHEMBL6624979 | 0.74 | MAPK8 (0.45) | PIM3PIM1MPLJAK2NR4A2 | |
| SCHEMBL2449538 | 0.73 | PBRM1 (0.51) | PIM3PIM1MPLJAK2NR4A2 | |
| SCHEMBL8487413 | 0.73 | JAK2 (0.52) | PIM3PIM1MPLJAK2NR4A2 | |
| SCHEMBL9485757 | 0.71 | MPL (0.61) | PIM3PIM1MPLNR4A2CREBBP | |
| SCHEMBL22230076 | 0.71 | PARP1 (0.53) | PIM3CHEK1PIM1NR4A2CREBBP | |
| SCHEMBL29532188 | 0.71 | PARP1 (0.53) | PIM3CHEK1PIM1NR4A2CREBBP | |
| SCHEMBL13659540 | 0.71 | CHEK1 (0.73) | PIM3CHEK1PIM1MPLNR4A2 | |
| SCHEMBL30136593 | 0.71 | KEAP1 (0.64) | PIM3PIM1NR4A2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831094-B1 | FUSED POLYCYCLIC HETEROCYCLE DERIVATIVES | EISAI CO LTD (JP) | 2004-12-08 | — | — | EP | disclosed |
| US-5952335-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| CN-1185781-A | Fused Polycyclic Heterocyclic Derivatives | EISAI CO LTD (JP) | 1998-06-24 | — | — | CN | disclosed |
| EP-0831094-A1 | FUSED POLYCYCLIC HETEROCYCLE DERIVATIVES | Eisai Co., Ltd. (JP) | 1998-03-25 | — | — | EP | disclosed |