Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19549753 | 0.77 | GAA (0.50) | GAATHRBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL19308460 | 0.72 | RAB9A (0.52) | GAATHRBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1722219 | 0.72 | RAB9A (0.55) | GAATHRBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL30593991 | 0.70 | RAB9A (0.57) | GAATHRBRAB9AKMT2ANPC1 | |
| SCHEMBL1934753 | 0.70 | RAB9A (0.57) | GAATHRBRAB9AKMT2ANPC1 | |
| SCHEMBL14559576 | 0.69 | MAPK1 (0.62) | GAARAB9AKMT2ANPC1KDM4E | |
| SCHEMBL4237518 | 0.69 | RAB9A (0.56) | GAATHRBRAB9AKMT2ANPC1 | |
| SCHEMBL4208169 | 0.69 | KMT2A (0.54) | GAARAB9AKMT2ANPC1KDM4E | |
| SCHEMBL5381046 | 0.69 | KDM4E (0.69) | GAARAB9AKMT2ANPC1KDM4E | |
| SCHEMBL14380664 | 0.68 | RAB9A (0.56) | GAATHRBCHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456172-A1 | PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003053925-A1 | PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-07-03 | — | — | WO | disclosed |