SCHEMBL6625536

SCHEMBL6625536

Cn1c(-c2ccccc2)c2c3c(cccc31)C(N)CC2

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.49
ALDH1A1 P00352 4/20 0.35
LMNA P02545 1/20 0.35
ACHE P22303 2/20 0.34
HK1 P19367 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HKDC1 Q2TB90 1/20 0.34
ANPEP P15144 4/20 0.34
HSD17B10 Q99714 2/20 0.34
IL1RN P18510 2/20 0.34
ERAP2 Q6P179 2/20 0.34
ERAP1 Q9NZ08 2/20 0.34
CYP2C19 P33261 1/20 0.34
HPGD P15428 1/20 0.33
PABPC1 P11940 1/20 0.32
CASP3 P42574 1/20 0.32
CASP7 P55210 1/20 0.32
CASP9 P55211 1/20 0.32
CASP6 P55212 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6626876 0.99 PARP1 (0.48) PARP1ALDH1A1LMNAACHEHK1
SCHEMBL6622858 0.81 SLC18A3 (0.35) PARP1ALDH1A1LMNAACHEANPEP
SCHEMBL6624364 0.78 KDM4E (0.40) ACHEHSD17B10CASP7
SCHEMBL6624136 0.77 PARP1 (0.43) PARP1ALDH1A1LMNAACHEHSD17B10
Hydrochloric Acid SCHEMBL6624034 0.76 PARP1 (0.42) PARP1ALDH1A1LMNAACHEHSD17B10
SCHEMBL6623150 0.76 KDM4E (0.41) ALDH1A1LMNAACHESMN1; SMN2HSD17B10
Hydrochloric Acid SCHEMBL6626356 0.74 PARP1 (0.43) PARP1ALDH1A1LMNAACHEHK1
SCHEMBL6626911 0.71 PARP1 (0.40) PARP1ALDH1A1LMNAACHEHK1
SCHEMBL6625499 0.70 HTR1A (0.31)
Hydrochloric Acid SCHEMBL6627074 0.70 PARP1 (0.39) PARP1ALDH1A1LMNAACHEHK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0858996-B1 NERVE CELL PROTECTIVE AGENTS MOCHIDA PHARM CO LTD (JP) 2004-10-27 EP disclosed
US-6040331-A Nerve cell protective agents MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-21 US disclosed
EP-0858996-A1 NERVE CELL PROTECTIVE AGENTS MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1998-08-19 EP disclosed