SCHEMBL6625499

SCHEMBL6625499

Cn1c(-c2ccc(Cl)cc2)c2c3c(ccc(Cl)c31)C(N)CC2

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 2/20 0.31
HTR7 P34969 2/20 0.31
CNR1 P21554 1/20 0.30
POLB P06746 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6624720 0.99 CNR1 (0.31) HTR1AHTR7CNR1
SCHEMBL6625286 0.72 CNR1 (0.34) CNR1POLBMAPT
SCHEMBL6625536 0.70 PARP1 (0.49)
SCHEMBL6626429 0.69 HTT (0.38)
Hydrochloric Acid SCHEMBL6626876 0.69 PARP1 (0.48)
Hydrochloric Acid SCHEMBL8221158 0.68 HTT (0.37)
SCHEMBL6624238 0.67 KDM4E (0.39) MAPT
SCHEMBL8824030 0.63 KDM4E (0.35) HTR1AHTR7MAPT
SCHEMBL11578773 0.63 ACHE (0.38)
SCHEMBL21752101 0.62 ADRA2A (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0858996-B1 NERVE CELL PROTECTIVE AGENTS MOCHIDA PHARM CO LTD (JP) 2004-10-27 EP disclosed
US-6040331-A Nerve cell protective agents MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-21 US disclosed
EP-0858996-A1 NERVE CELL PROTECTIVE AGENTS MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1998-08-19 EP disclosed