Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5034199 | 0.82 | CHRNB2 (0.56) | CHRNB2CHRNA4SLC6A7AKR1C3 | |
| SCHEMBL5034040 | 0.82 | CHRNB2 (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4AKR1C3 | |
| SCHEMBL6628645 | 0.82 | CHRNB2 (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4AKR1C3 | |
| SCHEMBL5038365 | 0.82 | CHRNB2 (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4AKR1C3 | |
| SCHEMBL11963203 | 0.82 | CHRNB2 (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4AKR1C3 | |
| SCHEMBL5036684 | 0.80 | CHRNB2 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL5038467 | 0.80 | CHRNB2 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4AKR1C3 | |
| SCHEMBL5043575 | 0.79 | GPR119 (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL5043499 | 0.79 | GPR119 (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL5037322 | 0.79 | CHRNB2 (0.55) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144413-B1 | 2,5-DIAZABICYCLO 2.2.1]HEPTANE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USES | SANOFI SYNTHELABO (FR) | 2004-03-17 | — | — | EP | disclosed |
| US-6635645-B1 | Nicotinic receptors dysfunction | SANOFI-SYNTHELABO (FR) | 2003-10-21 | — | — | US | disclosed |