Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL6625874

CN1CCC(CC(=O)NO)CC1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

nearest known ligand 0.38

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 2/20 0.38
NFE2L2 Q16236 2/20 0.38
ENPP1 P22413 1/20 0.37
DPP8 Q6V1X1 1/20 0.36
DPP7 Q9UHL4 1/20 0.36
NCF1 P14598 1/20 0.35
HDAC6 Q9UBN7 6/20 0.35
HDAC1 Q13547 5/20 0.35
GNAI3 P08754 1/20 0.35
GNAO1 P09471 1/20 0.35
GNAI1 P63096 1/20 0.35
HDAC3 O15379 4/20 0.35
HDAC4 P56524 4/20 0.35
HDAC7 Q8WUI4 4/20 0.35
HDAC2 Q92769 4/20 0.35
HDAC10 Q969S8 4/20 0.35
HDAC11 Q96DB2 4/20 0.35
HDAC8 Q9BY41 4/20 0.35
HDAC9 Q9UKV0 4/20 0.35
HDAC5 Q9UQL6 4/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL6631199 1.00 KEAP1 (0.38) KEAP1NFE2L2ENPP1DPP8DPP7
Trifluoroacetic Acid SCHEMBL6627251 0.84 DPP8 (0.39) ENPP1DPP8DPP7HDAC6HDAC1
Trifluoroacetic Acid SCHEMBL6626913 0.82 EPHX2 (0.42) DPP8DPP7HDAC6HDAC1HDAC3
Trifluoroacetic Acid SCHEMBL6631761 0.82 HDAC3 (0.41) HDAC6HDAC1HDAC3HDAC4HDAC7
Trifluoroacetic Acid SCHEMBL6627244 0.82 HDAC3 (0.41) HDAC6HDAC1HDAC3HDAC4HDAC7
Trifluoroacetic Acid SCHEMBL6629104 0.78 EPHX1 (0.45) EPHX1ITGB3ITGA2B
Trifluoroacetic Acid SCHEMBL6632396 0.78 EPHX1 (0.45) EPHX1ITGB3ITGA2B
Trifluoroacetic Acid SCHEMBL6626871 0.78 EPHX1 (0.45) EPHX1ITGB3ITGA2B
SCHEMBL29187171 0.76 LIPA (0.42) KEAP1NFE2L2NCF1GNAI3GNAO1
SCHEMBL26273947 0.76 KEAP1 (0.43) KEAP1NFE2L2NCF1GNAI3GNAO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027332-B1 NOVEL LACTAM METALLOPROTEASE INHIBITORS BRISTOL MYERS SQUIBB PHARMA CO (US) 2004-05-26 EP disclosed