Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.49 |
| ▸ | HTR3B | O95264 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 2/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953020 | 0.76 | HTR3E (0.50) | HTR1AHTR3EHTR3BHTR2CHTR3A | |
| SCHEMBL2628934 | 0.71 | HRH1 (0.57) | HTR1AHTR3EHTR3BHTR2CHTR3A | |
| SCHEMBL2961731 | 0.69 | HTR3E (0.54) | HTR1AHTR3EHTR3BHTR2CHTR3A | |
| SCHEMBL576868 | 0.69 | SIGMAR1 (1.00) | MC4RDRD4SIGMAR1KMT2ALMNA | |
| SCHEMBL1041303 | 0.69 | SIGMAR1 (1.00) | MC4RDRD4SIGMAR1KMT2ALMNA | |
| SCHEMBL2489199 | 0.69 | SIGMAR1 (1.00) | MC4RDRD4SIGMAR1KMT2ALMNA | |
| SCHEMBL1415730 | 0.69 | SIGMAR1 (1.00) | MC4RDRD4SIGMAR1KMT2ALMNA | |
| SCHEMBL8188324 | 0.69 | SIGMAR1 (1.00) | MC4RDRD4SIGMAR1KMT2ALMNA | |
| SCHEMBL242970 | 0.69 | SIGMAR1 (1.00) | MC4RDRD4SIGMAR1KMT2ALMNA | |
| SCHEMBL7827209 | 0.68 | SIGMAR1 (0.60) | MC4RDRD4SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392676-A2 | HETEROCYCLIC UREA DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | Aventis Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002066468-A2 | HETEROCYCLIC UREA DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | AVENTIS PHARMACEUTICALS INC. (US) | 2002-08-29 | — | — | WO | disclosed |