Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.41 |
| ▸ | KDM6B | O15054 | 3/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626490 | 0.88 | ALDH1A1 (0.43) | KDM4CKDM6BCYP2E1CYP2C8CYP2D6 | |
| SCHEMBL258369 | 0.81 | KDM4C (0.51) | PTGDR2KDM4CKDM6BCYP2E1CYP2C8 | |
| SCHEMBL4734614 | 0.81 | CYP2E1 (0.43) | PTGDR2KDM4CKDM6BCYP2E1CYP2C8 | |
| Hydrochloric Acid SCHEMBL5739434 | 0.80 | KDM4C (0.50) | PTGDR2KDM4CKDM6BCYP2E1CYP2C8 | |
| SCHEMBL16610646 | 0.76 | CYP2E1 (0.39) | PTGDR2KDM4CKDM6BCYP2E1CYP2C8 | |
| SCHEMBL4974313 | 0.76 | SIRT3 (0.59) | PTGDR2KDM4CKDM6BCYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL3092651 | 0.75 | SIRT3 (0.58) | PTGDR2KDM4CKDM6BCYP2E1CYP2C8 | |
| SCHEMBL9517606 | 0.75 | CYP2E1 (0.43) | PTGDR2KDM4CKDM6BCYP2E1CYP2C8 | |
| SCHEMBL6627688 | 0.73 | CYP2A6 (0.45) | PTGDR2KDM4CKDM6BCYP2E1CYP2C8 | |
| SCHEMBL18599002 | 0.72 | KDM6B (0.43) | PTGDR2KDM4CKDM6BSIRT3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040267017-A1 | 3-pyridyl or 4-isoquinolinyl thiazoles as c17, 20 lyase inhibitors | BAYER PHARMACEUTICALS CORPORATION | 2004-12-30 | — | — | US | disclosed |
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040267017-A1 | 3-pyridyl or 4-isoquinolinyl thiazoles as c17, 20 lyase inhibitors | CYP17A1, CYP21A2, HSD17B1 | PTGDR2 2249/4885KDM4C 512/4885KDM6B 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.