Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.65 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.60 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.55 |
| ▸ | CCKBR | P32239 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 4/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDK7 | P50613 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | CCNH | P51946 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5692826 | 0.81 | GABRA1 (0.64) | GABRA1PFKFB3PFKFB4CCKBRMMP8 | |
| SCHEMBL13211036 | 0.81 | GABRA1 (0.69) | GABRA1PFKFB3PFKFB4CCKBRMMP8 | |
| SCHEMBL5385965 | 0.78 | GABRA1 (0.61) | GABRA1PFKFB3PFKFB4CCKBRMMP8 | |
| SCHEMBL8280458 | 0.77 | GABRA1 (0.77) | GABRA1PFKFB3PFKFB4CCKBRMMP8 | |
| SCHEMBL13633919 | 0.76 | GABRA1 (0.72) | GABRA1PFKFB3PFKFB4CCKBRMMP8 | |
| SCHEMBL13633864 | 0.76 | GABRA1 (0.62) | GABRA1PFKFB3PFKFB4CCKBRMMP8 | |
| SCHEMBL787849 | 0.76 | GABRA1 (0.65) | GABRA1PFKFB3PFKFB4CCKBRMMP8 | |
| SCHEMBL12179846 | 0.76 | GABRA1 (0.61) | GABRA1PFKFB3PFKFB4CCKBRMMP8 | |
| SCHEMBL4008105 | 0.76 | GABRA1 (0.61) | GABRA1PFKFB3PFKFB4CCKBRMMP8 | |
| SCHEMBL2197723 | 0.76 | GABRA1 (0.61) | GABRA1PFKFB3PFKFB4CCKBRMMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | claimed |
| WO-2003043999-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | claimed |
| WO-2004112782-A1 | NEW USE V | BIOVITRUM AB (SE) | 2004-12-29 | — | — | WO | disclosed |