Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21045867 | 1.00 | LMNA (0.47) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| SCHEMBL29242642 | 0.85 | LMNA (0.53) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| SCHEMBL10769127 | 0.84 | LMNA (0.31) | LMNAL3MBTL1 | |
| E968 SCHEMBL13727065 | 0.80 | LMNA (0.67) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| E968 SCHEMBL6729753 | 0.80 | — | — | |
| E968 SCHEMBL121807 | 0.80 | — | — | |
| E968 SCHEMBL17062 | 0.80 | — | — | |
| E968 SCHEMBL10427336 | 0.80 | — | — | |
| E968 SCHEMBL17766 | 0.80 | — | — | |
| E968 SCHEMBL1697009 | 0.80 | LMNA (0.67) | LMNAL3MBTL1TDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1063986-A4 | COMPOUNDS AND METHODS FOR USE IN TREATING NEOPLASIA, CANCER, HYPERPROLIFERATIVE CELL GROWTH AND CHRONIC INFLAMMATORY DISEASES | THEREX TECHNOLOGIES INC (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-1063986-A1 | COMPOUNDS AND METHODS FOR USE IN TREATING NEOPLASIA, CANCER, HYPERPROLIFERATIVE CELL GROWTH AND CHRONIC INFLAMMATORY DISEASES | Therex Technologies, Inc. (US) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999043313-A1 | COMPOUNDS AND METHODS FOR USE IN TREATING NEOPLASIA, CANCER, HYPERPROLIFERATIVE CELL GROWTH AND CHRONIC INFLAMMATORY DISEASES | THEREX TECHNOLOGIES, INC. (US) | 1999-09-02 | — | — | WO | disclosed |