Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.50 |
| ▸ | HTR2A | P28223 | 8/20 | 0.50 |
| ▸ | HTR2B | P41595 | 6/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629013 | 0.85 | HTR2C (0.66) | HTR2CHTR2AHTR2BDRD2DRD3 | |
| SCHEMBL6411291 | 0.80 | HTR2C (0.76) | HTR2CHTR2AHTR2BDRD3ADRA1B | |
| SCHEMBL6628271 | 0.77 | HTR2C (0.69) | HTR2CHTR2AHTR2BDRD2DRD3 | |
| SCHEMBL6629920 | 0.76 | HTR2C (0.70) | HTR2CHTR2AHTR2BDRD2DRD3 | |
| SCHEMBL6630061 | 0.76 | HTR2C (0.66) | HTR2CHTR2AHTR2BDRD2DRD3 | |
| SCHEMBL6628642 | 0.73 | HTR2C (0.68) | HTR2CHTR2AHTR2BDRD2DRD3 | |
| SCHEMBL6608189 | 0.72 | LTA4H (0.49) | — | |
| SCHEMBL6628017 | 0.71 | HTR2C (0.69) | HTR2CHTR2AHTR2BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7323126 | 0.71 | LTA4H (0.48) | — | |
| SCHEMBL11449282 | 0.70 | PIM1 (0.47) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465630-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057220-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2003-07-17 | — | — | WO | disclosed |