Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | CASP3 | P42574 | 2/20 | 0.70 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.70 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.70 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.70 |
| ▸ | IKBKB | O14920 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4096459 | 0.95 | MAPT (0.78) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL6612856 | 0.90 | MAPT (0.70) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL1531346 | 0.83 | MAPT (1.00) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL431794 | 0.83 | MAPT (0.74) | MAPTKDM4ERAB9ANPC1CASP3 | |
| Hydrochloric Acid SCHEMBL8864118 | 0.82 | MAPT (0.72) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL4081426 | 0.81 | MAPT (0.67) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL1405912 | 0.80 | IKBKB (0.78) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL4086036 | 0.79 | IKBKB (0.60) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL4086753 | 0.79 | IKBKB (0.75) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL10070140 | 0.77 | MAPT (0.78) | MAPTKDM4ERAB9ANPC1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261600-B1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | ASTRAZENECA AB (SE) | 2004-05-06 | — | — | EP | disclosed |