Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.78 |
| ▸ | RAB9A | P51151 | 5/20 | 0.78 |
| ▸ | NPC1 | O15118 | 4/20 | 0.78 |
| ▸ | CASP3 | P42574 | 2/20 | 0.78 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.78 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.78 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.78 |
| ▸ | IKBKB | O14920 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6612856 | 0.95 | MAPT (0.70) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL6628323 | 0.95 | MAPT (0.70) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL1531346 | 0.87 | MAPT (1.00) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL431794 | 0.87 | MAPT (0.74) | MAPTKDM4ERAB9ANPC1CASP3 | |
| Hydrochloric Acid SCHEMBL8864118 | 0.86 | MAPT (0.72) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL4081426 | 0.85 | MAPT (0.67) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL1405912 | 0.84 | IKBKB (0.78) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL4086036 | 0.83 | IKBKB (0.60) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL4086753 | 0.83 | IKBKB (0.75) | MAPTKDM4ERAB9ANPC1CASP3 | |
| SCHEMBL10070140 | 0.81 | MAPT (0.78) | MAPTKDM4ERAB9ANPC1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399322-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2023-12-14 | — | — | US | disclosed |
| US-20230399322-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2023-12-14 | — | — | US | disclosed |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| WO-2021178488-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. (US) | 2021-09-10 | — | — | WO | disclosed |
| US-20090181962-A1 | Substituted thiophene compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2009-07-16 | — | — | US | disclosed |
| US-7358376-B2 | Substituted Thiophene compounds | ASTRAZENECA AB (SE) | 2008-04-15 | — | — | US | disclosed |
| US-6492364-B1 | Triazolo and derivatives as chemokine inhibitors | TORAY INDUSTRIES, INC. (JP) | 2002-12-10 | — | — | US | disclosed |
| EP-1261600-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | AstraZeneca AB (SE) | 2002-12-04 | — | — | EP | disclosed |
| US-6441019-B2 | E. G., 6-(3-CHLOROPHENYL)-1,4-DIHYDRO-4,4-DIMETHYL-2H-THIENO-(2,3-D)(1,3) OXAZINE-2-ONE; AGONISTS AND ANTAGONISTS OF THE PROGESTERONE RECEPTOR; INDUCING CONTRACEPTION AND TREATING OR PREVENTING BENIGN OR MALIGNANT NEOPLASTIC DISEASES | WYETH | 2002-08-27 | — | — | US | disclosed |
| CN-1349538-A | Cyclic carbamate and cyclic amide derivatives | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| US-6380178-B1 | CONTRACEPTION WHICH COMPRISES ADMINISTERING TO A FEMALE OF FOR 28 CONSECUTIVE DAYS: FIRST PHASE OF FROM 14 TO 24 DAILY DOSAGE UNITS OF A PROGESTATIONAL AGENT LEVONORGESTREL; SECOND PHASE OF FROM 1 TO 11 DAILY DOSAGE UNITS OF ANTIPROGESTIN COMPOUND | AMERICAN HOME PRODUCTS CORPORATION | 2002-04-30 | — | — | US | disclosed |
| EP-1185535-A1 | CYCLOCARBAMATE AND CYCLIC AMIDE DERIVATIVES | American Home Products Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| US-20020002173-A1 | Cyclocarbamate and cyclic amide derivatives | LIGAND PHARMACEUTICALS INCORPORATED | 2002-01-03 | — | — | US | disclosed |
| US-6306851-B1 | ADMINISTERING TO A MAMMAL A COMPOUND FOR BENIGN OR MALIGNANT NEOPLASTIC DISEASE IS SELECTED FROM UTERINE MYOMETRIAL FIBROIDS, ENDOMETRIOSIS, BENIGN PROSTATIC HYPERTROPHY; | AMERICAN HOME PRODUCTS CORPORATION | 2001-10-23 | — | — | US | disclosed |
| WO-2001058890-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | WO | disclosed |
| EP-1067130-A1 | TRIAZOLO DERIVATIVES AND CHEMOKINE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 2001-01-10 | — | — | EP | disclosed |
| WO-2000066591-A1 | CYCLOCARBAMATE AND CYCLIC AMIDE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |
| US-4710506-A | Antihypertensive thienopyridines | THE BOOTS COMPANY PLC (GB) | 1987-12-01 | — | — | US | disclosed |
| EP-0209977-A2 | Thienopyridones, processes and intermediates for their preparation and pharmaceutical compositions containing them | The Boots Company PLC (GB) | 1987-01-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181962-A1 | Substituted thiophene compounds | ABCG2, SULT1E1, TPMT | MAPT 2469/4885KDM4E 652/4885RAB9A 2237/4885 |
| US-20230399322-A1 | EIF4E INHIBITORS AND USES THEREOF | EIF4E, EIF4EBP1, EIF4A1 | MAPT 2231/4885KDM4E 710/4885RAB9A 1568/4885 |
| US-20020002173-A1 | Cyclocarbamate and cyclic amide derivatives | CNR1, PGR, NR5A1 | MAPT 4814/4885KDM4E 3285/4885RAB9A 4234/4885 |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | EIF4E, EIF4EBP1, EIF4A1 | MAPT 2231/4885KDM4E 710/4885RAB9A 1568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.