Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27286630 | 0.83 | ALDH1A1 (0.45) | ALDH1A1PREP | |
| SCHEMBL7845558 | 0.81 | ALDH1A1 (0.44) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4701620 | 0.81 | ALDH1A1 (0.44) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13244922 | 0.81 | ALDH1A1 (0.44) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4701828 | 0.80 | ALDH1A1 (0.43) | ALDH1A1PREPSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4700390 | 0.80 | ALDH1A1 (0.43) | ALDH1A1PREPSMN1; SMN2 | |
| SCHEMBL23163149 | 0.78 | PREP (0.44) | ALDH1A1PREPSMN1; SMN2CTSLCTSB | |
| SCHEMBL4698575 | 0.78 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL4698569 | 0.77 | SMN1; SMN2 (0.48) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13244810 | 0.76 | ALDH1A1 (0.42) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444202-A1 | NOVEL METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040098-A1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |