Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.62 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.62 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12655119 | 0.87 | KMT2A (0.78) | NPC1RAB9ASMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL10439393 | 0.86 | CYP1A2 (0.86) | NPC1RAB9ASMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL28089994 | 0.86 | KMT2A (0.64) | NPC1RAB9ASMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL13601054 | 0.85 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2KMT2AKCNK3 | |
| SCHEMBL6962290 | 0.85 | CYP1A2 (0.65) | NPC1RAB9ASMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL29831035 | 0.84 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2KMT2AKCNK3 | |
| SCHEMBL7152809 | 0.84 | FFAR1 (0.75) | NPC1RAB9ASMN1; SMN2KMT2AKCNK3 | |
| SCHEMBL5226157 | 0.83 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2KMT2AKCNK3 | |
| SCHEMBL13104410 | 0.81 | SIRT1 (0.68) | NPC1RAB9AKMT2ACYP1A2KCNK3 | |
| SCHEMBL8374911 | 0.81 | HDAC1 (0.85) | NPC1RAB9ASMN1; SMN2KMT2AKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |