Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 10/20 | 0.38 |
| ▸ | CTH | P32929 | 1/20 | 0.37 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | USP9X | Q93008 | 2/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | USP5 | P45974 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31546777 | 0.85 | IRAK4 (0.38) | STAT3CTHIRAK4HSD11B1 | |
| SCHEMBL30242716 | 0.85 | IRAK4 (0.38) | STAT3CTHIRAK4HSD11B1 | |
| SCHEMBL15447728 | 0.85 | IRAK4 (0.38) | STAT3CTHIRAK4HSD11B1 | |
| SCHEMBL400366 | 0.85 | IRAK4 (0.38) | STAT3CTHIRAK4HSD11B1 | |
| SCHEMBL2036719 | 0.85 | IRAK4 (0.38) | STAT3CTHIRAK4HSD11B1 | |
| SCHEMBL29792032 | 0.81 | — | — | |
| SCHEMBL104173 | 0.81 | — | — | |
| SCHEMBL2559906 | 0.76 | CCR1 (0.40) | TERTSLC10A1HSD11B1CCR1 | |
| SCHEMBL27801484 | 0.73 | IRAK4 (0.39) | STAT3IRAK4 | |
| Pyrimidine SCHEMBL29174127 | 0.71 | TERT (0.39) | STAT3TERTCTHUSP9XCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | disclosed |