Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 16/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 9/20 | 0.43 |
| ▸ | CTSK | P43235 | 8/20 | 0.43 |
| ▸ | CTSB | P07858 | 7/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656008 | 0.82 | CTSS (0.47) | CTSSCTSLCTSKCTSB | |
| SCHEMBL6063338 | 0.81 | CTSS (0.44) | CTSSMEN1KMT2ANPSR1CTSL | |
| SCHEMBL6063336 | 0.81 | CTSS (0.44) | CTSSMEN1KMT2ANPSR1CTSL | |
| SCHEMBL6628713 | 0.78 | CTSS (0.47) | CTSSMEN1KMT2ANPSR1CTSL | |
| SCHEMBL6628710 | 0.78 | CTSS (0.47) | CTSSMEN1KMT2ANPSR1CTSL | |
| SCHEMBL5955838 | 0.73 | CTSS (0.60) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7656003 | 0.73 | CTSS (0.55) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7655999 | 0.73 | CTSS (0.55) | CTSSCTSLCTSKCTSB | |
| SCHEMBL3907834 | 0.72 | CTSS (0.50) | CTSSMEN1KMT2ANPSR1CTSL | |
| SCHEMBL3893947 | 0.70 | CTSS (0.48) | CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |