Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.64 |
| ▸ | HTR2B | P41595 | 10/20 | 0.64 |
| ▸ | HTR2A | P28223 | 6/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6671592 | 0.85 | HTR2C (0.65) | HTR2CHTR2BHTR2A | |
| SCHEMBL6673289 | 0.85 | HTR2C (0.59) | HTR2CHTR2BHTR2AMCHR1 | |
| SCHEMBL6632359 | 0.84 | HTR2C (0.67) | HTR2CHTR2BHTR2AKCNH2MCHR1 | |
| SCHEMBL6413793 | 0.78 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL6629424 | 0.77 | HTR7 (0.43) | HTR2CHTR2B | |
| SCHEMBL6628069 | 0.74 | PDE4A (0.47) | HTR2CHTR2BHTR2A | |
| SCHEMBL6629684 | 0.73 | PDE4A (0.55) | HTR2CHTR2BHTR2A | |
| SCHEMBL4025894 | 0.73 | HTR2C (0.73) | HTR2CHTR2BHTR2A | |
| SCHEMBL4025779 | 0.72 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL6408486 | 0.69 | HTR2C (1.00) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265900-A4 | 1,5-DISUBSTITUTED-3,4-DIHYDRO-1H-PYRIMIDO 4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES | SMITHKLINE BEECHAM CORP (US) | 2004-11-10 | — | — | EP | claimed |
| EP-1265900-A1 | 1,5-DISUBSTITUTED-3,4-DIHYDRO-1H-PYRIMIDO 4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES | SmithKline Beecham Corporation (US) | 2002-12-18 | — | — | EP | claimed |
| WO-2001064679-A1 | 1,5-DISUBSTITUTED-3,4-DIHYDRO-1H-PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-07 | — | — | WO | claimed |