Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | HTR2B | P41595 | 4/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628069 | 0.93 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL6628744 | 0.80 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL6673289 | 0.78 | HTR2C (0.59) | HTR2CHTR2BHTR2A | |
| SCHEMBL6629424 | 0.75 | HTR7 (0.43) | HTR2CHTR2BHSD11B1POLB | |
| SCHEMBL6414662 | 0.75 | HTR2C (0.72) | HTR2CHTR2BHTR2APOLBFFAR1 | |
| SCHEMBL6629267 | 0.73 | HTR2C (0.64) | HTR2CHTR2BHTR2A | |
| SCHEMBL6629235 | 0.73 | MAPT (0.55) | PDE4APDE4BPDE4CPDE4DTDP1 | |
| SCHEMBL6412122 | 0.72 | HTR2C (0.56) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL24167886 | 0.71 | PDE4B (0.54) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL20707986 | 0.71 | PDE4B (0.54) | PDE4APDE4BPDE4CPDE4DHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465630-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057220-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2003-07-17 | — | — | WO | disclosed |