Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6627826 | 0.78 | KMT2A (0.48) | TP53NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL1720197 | 0.69 | NPC1 (0.67) | NPC1RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL6630894 | 0.69 | NPC1 (0.42) | NPC1RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL6631510 | 0.68 | CYP1A2 (0.44) | NPC1RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL4403976 | 0.68 | ITGB1 (0.55) | NPC1RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL15165521 | 0.68 | TP53 (0.59) | TP53NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL2096115 | 0.67 | NPC1 (0.62) | NPC1RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL13506261 | 0.67 | HPGD (0.51) | TP53NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL27714667 | 0.66 | KMT2A (0.57) | NPC1RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL6677140 | 0.66 | HPGD (0.47) | NPC1RAB9AALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |